Transformation of lamotrigine by white-rot fungus Pleurotus ostreatus.
Identifieur interne : 000196 ( Main/Exploration ); précédent : 000195; suivant : 000197Transformation of lamotrigine by white-rot fungus Pleurotus ostreatus.
Auteurs : Benny Chefetz [Israël] ; Rotem Marom [Israël] ; Orit Salton [Israël] ; Mariana Oliferovsky [Israël] ; Vered Mordehay [Israël] ; Julius Ben-Ari [Israël] ; Yitzhak Hadar [Israël]Source :
- Environmental pollution (Barking, Essex : 1987) [ 1873-6424 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- composition chimique : Eaux usées.
- microbiologie : Eaux usées.
- métabolisme : Lamotrigine, Pleurotus, Polluants chimiques de l'eau.
- Dépollution biologique de l'environnement.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Waste Water.
- chemical , metabolism : Lamotrigine, Water Pollutants, Chemical.
- metabolism : Pleurotus.
- chemical , microbiology : Waste Water.
- Biodegradation, Environmental.
Abstract
One of the most persistent pharmaceutical compounds commonly found in treated wastewater is lamotrigine (LTG). It has also been detected in soils and crops irrigated with treated wastewater. Here we focused on the ability of the white-rot edible mushroom Pleurotus ostreatus to remove and transform LTG in liquid cultures. At concentrations of environmental relevance (1 and 10 μg L-1) LTG was almost completely removed from the culture medium within 20 days. To elucidate the mechanism of LTG removal and transformation, we applied a physiological-based approach using inhibitors and a competing agent. These experiments were conducted at a higher concentration for metabolites detection. Based on identification of sulfur-containing metabolites and LTG N2-oxide and the effect of specific inhibitors, cytochrome P450 oxidation is suggested as one of the reaction mechanisms leading to LTG transformation. The variety and number of transformation products (i.e., conjugates) found in the current study were larger than reported in mammals. Moreover, known conjugates with glucuronide, glutathione, or cysteine/glycine, were not found in our system. Since the majority of the identified transformation products were conjugates of LTG, this study highlights the persistence of LTG as an organic pollutant in ecosystems exposed to wastewater.
DOI: 10.1016/j.envpol.2019.04.057
PubMed: 31026702
Affiliations:
Links toward previous steps (curation, corpus...)
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Electronic address: benny.chefetz@mail.huji.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author><author><name sortKey="Marom, Rotem" sort="Marom, Rotem" uniqKey="Marom R" first="Rotem" last="Marom">Rotem Marom</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author><author><name sortKey="Salton, Orit" sort="Salton, Orit" uniqKey="Salton O" first="Orit" last="Salton">Orit Salton</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author><author><name sortKey="Oliferovsky, Mariana" sort="Oliferovsky, Mariana" uniqKey="Oliferovsky M" first="Mariana" last="Oliferovsky">Mariana Oliferovsky</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author><author><name sortKey="Mordehay, Vered" sort="Mordehay, Vered" uniqKey="Mordehay V" first="Vered" last="Mordehay">Vered Mordehay</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author><author><name sortKey="Ben Ari, Julius" sort="Ben Ari, Julius" uniqKey="Ben Ari J" first="Julius" last="Ben-Ari">Julius Ben-Ari</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author><author><name sortKey="Hadar, Yitzhak" sort="Hadar, Yitzhak" uniqKey="Hadar Y" first="Yitzhak" last="Hadar">Yitzhak Hadar</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel. Electronic address: yitzhak.hadar@mail.huji.ac.il.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001</wicri:regionArea><wicri:noRegion>7610001</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental pollution (Barking, Essex : 1987)</title><idno type="eISSN">1873-6424</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biodegradation, Environmental (MeSH)</term><term>Lamotrigine (metabolism)</term><term>Pleurotus (metabolism)</term><term>Waste Water (chemistry)</term><term>Waste Water (microbiology)</term><term>Water Pollutants, Chemical (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Dépollution biologique de l'environnement (MeSH)</term><term>Eaux usées (composition chimique)</term><term>Eaux usées (microbiologie)</term><term>Lamotrigine (métabolisme)</term><term>Pleurotus (métabolisme)</term><term>Polluants chimiques de l'eau (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Waste Water</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lamotrigine</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Eaux usées</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Pleurotus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Eaux usées</term></keywords><keywords scheme="MESH" type="chemical" qualifier="microbiology" xml:lang="en"><term>Waste Water</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lamotrigine</term><term>Pleurotus</term><term>Polluants chimiques de l'eau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biodegradation, Environmental</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Dépollution biologique de l'environnement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One of the most persistent pharmaceutical compounds commonly found in treated wastewater is lamotrigine (LTG). It has also been detected in soils and crops irrigated with treated wastewater. Here we focused on the ability of the white-rot edible mushroom Pleurotus ostreatus to remove and transform LTG in liquid cultures. At concentrations of environmental relevance (1 and 10 μg L<sup>-1</sup>) LTG was almost completely removed from the culture medium within 20 days. To elucidate the mechanism of LTG removal and transformation, we applied a physiological-based approach using inhibitors and a competing agent. These experiments were conducted at a higher concentration for metabolites detection. Based on identification of sulfur-containing metabolites and LTG N2-oxide and the effect of specific inhibitors, cytochrome P450 oxidation is suggested as one of the reaction mechanisms leading to LTG transformation. The variety and number of transformation products (i.e., conjugates) found in the current study were larger than reported in mammals. Moreover, known conjugates with glucuronide, glutathione, or cysteine/glycine, were not found in our system. Since the majority of the identified transformation products were conjugates of LTG, this study highlights the persistence of LTG as an organic pollutant in ecosystems exposed to wastewater.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">31026702</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6424</ISSN><JournalIssue CitedMedium="Internet"><Volume>250</Volume><PubDate><Year>2019</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Environmental pollution (Barking, Essex : 1987)</Title><ISOAbbreviation>Environ Pollut</ISOAbbreviation></Journal><ArticleTitle>Transformation of lamotrigine by white-rot fungus Pleurotus ostreatus.</ArticleTitle><Pagination><MedlinePgn>546-553</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0269-7491(19)30328-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.envpol.2019.04.057</ELocationID><Abstract><AbstractText>One of the most persistent pharmaceutical compounds commonly found in treated wastewater is lamotrigine (LTG). It has also been detected in soils and crops irrigated with treated wastewater. Here we focused on the ability of the white-rot edible mushroom Pleurotus ostreatus to remove and transform LTG in liquid cultures. At concentrations of environmental relevance (1 and 10 μg L<sup>-1</sup>) LTG was almost completely removed from the culture medium within 20 days. To elucidate the mechanism of LTG removal and transformation, we applied a physiological-based approach using inhibitors and a competing agent. These experiments were conducted at a higher concentration for metabolites detection. Based on identification of sulfur-containing metabolites and LTG N2-oxide and the effect of specific inhibitors, cytochrome P450 oxidation is suggested as one of the reaction mechanisms leading to LTG transformation. The variety and number of transformation products (i.e., conjugates) found in the current study were larger than reported in mammals. Moreover, known conjugates with glucuronide, glutathione, or cysteine/glycine, were not found in our system. Since the majority of the identified transformation products were conjugates of LTG, this study highlights the persistence of LTG as an organic pollutant in ecosystems exposed to wastewater.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chefetz</LastName><ForeName>Benny</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel. Electronic address: benny.chefetz@mail.huji.ac.il.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marom</LastName><ForeName>Rotem</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salton</LastName><ForeName>Orit</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oliferovsky</LastName><ForeName>Mariana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mordehay</LastName><ForeName>Vered</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Ari</LastName><ForeName>Julius</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hadar</LastName><ForeName>Yitzhak</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel. Electronic address: yitzhak.hadar@mail.huji.ac.il.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Environ Pollut</MedlineTA><NlmUniqueID>8804476</NlmUniqueID><ISSNLinking>0269-7491</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D062065">Waste Water</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>U3H27498KS</RegistryNumber><NameOfSubstance UI="D000077213">Lamotrigine</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D001673" MajorTopicYN="Y">Biodegradation, Environmental</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077213" MajorTopicYN="N">Lamotrigine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020076" MajorTopicYN="N">Pleurotus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062065" MajorTopicYN="N">Waste Water</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>01</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>04</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31026702</ArticleId><ArticleId IdType="pii">S0269-7491(19)30328-8</ArticleId><ArticleId IdType="doi">10.1016/j.envpol.2019.04.057</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Chefetz, Benny" sort="Chefetz, Benny" uniqKey="Chefetz B" first="Benny" last="Chefetz">Benny Chefetz</name></noRegion><name sortKey="Ben Ari, Julius" sort="Ben Ari, Julius" uniqKey="Ben Ari J" first="Julius" last="Ben-Ari">Julius Ben-Ari</name><name sortKey="Hadar, Yitzhak" sort="Hadar, Yitzhak" uniqKey="Hadar Y" first="Yitzhak" last="Hadar">Yitzhak Hadar</name><name sortKey="Marom, Rotem" sort="Marom, Rotem" uniqKey="Marom R" first="Rotem" last="Marom">Rotem Marom</name><name sortKey="Mordehay, Vered" sort="Mordehay, Vered" uniqKey="Mordehay V" first="Vered" last="Mordehay">Vered Mordehay</name><name sortKey="Oliferovsky, Mariana" sort="Oliferovsky, Mariana" uniqKey="Oliferovsky M" first="Mariana" last="Oliferovsky">Mariana Oliferovsky</name><name sortKey="Salton, Orit" sort="Salton, Orit" uniqKey="Salton O" first="Orit" last="Salton">Orit Salton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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